Interventional bronchology AND pulmonology, year : 2016, volume :. Issue : 1, page : 20-25, ultrasound-guided pleurodesis with doxycycline in patients with hepatic hydrothorax. Ahmed M Abd El Hafeez, mD 1, Waleed F Fathallah 2 1 Department of pleurodesis with doxycycline Chest, pleurodesis with doxycycline Faculty pleurodesis with doxycycline of Medicine, Cairo University, Cairo, Egypt 2 Department of Tropical Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt. Date of Submission 07-Sep-2015, date of Acceptance 18-Oct-2015, date of Web Publication 17-Feb-2016, correspondence Address : Ahmed M Abd El Hafeez, department of Chest Diseases, Faculty of Medicine, Cairo University, 4 Esraa., Agouza, 12656 Giza. Egypt, source of Support: None, Conflict of Interest: None, check, dOI:.4103/1687-8426.176661, background, pleural effusion is a relatively uncommon complication of end-stage liver disease, which occurs in less than 10 of the patients. Patients with refractory hydrothorax pleurodesis with doxycycline require more invasive management with options such as repeated thoracentesis in selected patients, which usually carries risk for pneumothorax and contamination. Many studies have shown that doxycycline pleurodesis is an effective and safe method for achieving apposition of the pleural surfaces. Patients and methods, this prospective study included 60 patients with hepatic hydrothorax. All patients were subjected to repeated thoracentesis (two to four times) followed by the placement of a 16-G cannula under ultrasound guidance for proper drainage of any detected remnants of pleural fluid collections. In total, 10 ml of lidocaine 2 were injected in the pleural space followed by 1000 mg of doxycycline diluted in 100 ml saline solution. Pleurodesis session was repeated after 1 week if any radiological evidence for reaccumulation was noticed. The sclerotherapy procedure was successful in 46 out of 60 cases pleurodesis with doxycycline (76.7 the success rate was.2 in massive effusion and reached.3 in moderate effusion. A total pleurodesis with doxycycline of 26 patients (43.3) had to repeat the procedure for a second time, 14 of which (23.3) failed despite the second trial and 12 cases (20) showed no fluid reaccumulation. Conclusion, ultrasound-guided doxycycline sclerotherapy is an effective approach for a successful pleurodesis in hepatic hydrothorax (overall rate.7). The procedure is safe and precludes the need for intercostal tube insertion and thus offering less discomfort for patients. Keywords: doxycycline, pleurodesis, ultrasound, how to cite this article: Abd El Hafeez AM, Fathallah. Ultrasound-guided pleurodesis with doxycycline in patients with hepatic hydrothorax. Egypt J Bronchol 2016;10:20-5. How to cite this URL: Abd El Hafeez AM, Fathallah. Egypt J Bronchol serial online 20 May 25;10:20-5. Available from: p?2016/10/1/20/176661, pleural effusion is a relatively uncommon complication of end-stage liver disease, which occurs in less than 10 of the patients, typically located on the right side in 70-80 of the cases. Although right-sided pleural effusion can develop in the absence of significant ascites, coexisting ascites pleurodesis with doxycycline is normally present. The negative intrathoracic pressure draws ascitic fluid into the pleural space through the multiple natural defects in the diaphragm, like the 'pores of Kohn'. The underlying mechanisms for hepatic hydrothorax are similar to those leading to fluid accumulation and ascites in portal hypertension. Portal hypertension and splanchnic vasodilation plays an important role in the formation of ascites. Several mechanisms have been postulated for the development of hepatic hydrothorax in patients with liver cirrhosis. These include the transfer of the peritoneal fluid into the pleural space through diaphragmatic defects, hypoalbuminaemia resulting in decreased colloid osmotic pressure and lymphatic leakage from the thoracic duct. The direct passage of fluid from the peritoneal to the pleural cavity through diaphragmatic defects has been proposed as the most accepted mechanism explaining most cases of hepatic hydrothorax 3,. The composition of hepatic hydrothorax is transudative in nature and therefore similar to the ascitic fluid; it also has a serum to pleural fluid albumin gradient greater than.1, as is found in ascites secondary to portal hypertension.

What's doxycycline used for

Doxycycline oral what's doxycycline used for tablet is what's doxycycline used for available as both what's doxycycline used for a generic and brand-name drug. Brand names: Acticlate, Doryx, Doryx MPC. Doxycycline comes in three oral forms: a tablet, a capsule, and a suspension. It also comes as a solution for injection, which is only given by a healthcare provider. Doxycycline oral tablet is used to treat infections and severe acne. Its also used to prevent malaria. Doxycycline oral tablet is a prescription drug thats available as the brand-name drugs Acticlate, Doryx, and Doryx MPC. Its also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version. Doxycycline tablets what's doxycycline used for come in immediate-release and delayed-release forms. Doxycycline also comes in two other oral forms: capsule and solution. In addition, doxycycline comes in a solution for injection, which is only given by a healthcare provider. Why it's used, doxycycline is used to treat bacterial infections. These can include some sexually transmitted diseases, skin infections, eye infections, respiratory what's doxycycline used for infections, and more. It is also used as an add-on treatment for severe acne and to prevent malaria in people who plan to travel to areas with certain strains of what's doxycycline used for malaria. This drug may be used as part of a combination therapy. This means you may need to take it with other medications. How it works, doxycycline belongs to a class of drugs called tetracyclines. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. This drug works by blocking a bacterial protein from being what's doxycycline used for made. It does this by binding to certain units of the protein. This stops the protein from growing and treats your infection. Doxycycline oral tablet can cause side effects. Some are more common, and some are serious. More common side effects.

Doxycycline animals

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